Dr. David J. Brick


d_brickDr. David J. Brick, an Irish-born Virologist and Stem Cell Scientist, received his PhD (Biochemistry) from the University of Victoria, British Columbia. His thesis centered on the identification of an anti-apoptosis function for the RING finger motif N1R/P28 family of poxvirus virulence proteins. Dr. Brick mapped the DNA binding region to an N-terminal motif distinct from the RING finger domain that is now known as the KilA-N domain, and which is found in a wide range of proteins of large bacterial and eukaryotic DNA Viruses.

 Dr. Brick then completed post-doctoral training in neuroscience at the Cedar-Sinai Medical Center in Los Angeles. Dr. Brick is a full member of the American Society for Virology and a recipient of the Ruth L. Kirschstein National Institutes of Health (NIH) (F32) Individual Research Fellowship while at the University of California Irvine Medical Center in Orange. Dr. Brick was recruited to the Centers for Neuroscience Research and Translational Research at Children’s Hospital of Orange County Research Institute in 2007 to develop the Institute’s induced pluripotent stem cell (iPSC) laboratory. Dr. Brick is currently Scientist II at CHOC Children’s Research Institute and along with his colleague, Dr. Philip Schwartz, has received NIH R01 support to create a resource of Autism Spectrum Disorder (ASD) fibroblast and iPSC cell lines for basic research and distribution and California Institute for Regenerative Medicine (CIRM) Translational Research funding aimed at multimodal immune-matched stem cell transplantation for the treatment of the Lysosomal Storage Disease, Mucopolysaccharidosis-1 (Hurler’s Syndrome).